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Other Knee Treatments
Arthrosamid® Knee Injection in London
A Non-Surgical Solution for Knee Osteoarthritis
Whether you’re looking for the latest, holistic, biological knee treatments, faster access to care, or personalised support, our expert team is here to help. From non-surgical solutions to advanced minimally invasive surgeries, we specialise in delivering outstanding outcomes tailored to your needs.
Free 60-second assessment
How old are your knees?
Your knees have a biological age, and it is often not the age on your passport. Of the people who have taken this test, 55 per cent found their knees were older than they are, and one in eight by ten years or more. Sixty seconds, free, and you get one number and the single change that would take the most years off it.
Find my Knee Age, free →What Is Arthrosamid®?
Arthrosamid® is a non-surgical treatment for knee osteoarthritis offered by Dr Imbuldeniya at OrthoLongevity. This innovative polyacrylamide hydrogel treatment forms part of an Ortholongevity approach, focusing on preserving joint health, reducing pain and maintaining function for as long as possible without the need for early surgical intervention. It provides a long-lasting, injectable alternative to more invasive surgeries, such as knee replacements. Patients suffering from knee pain, joint stiffness and limited mobility can now benefit from this therapy, which cushions and lubricates the knee and improves joint function. The treatment is primarily offered at Lanserhof at The Arts Club in Mayfair, central London.
How Does Arthrosamid® Work?
Arthrosamid® is a 2.5% cross-linked polyacrylamide hydrogel which is a thick gel, injected directly into the synovial fluid of the knee joint using precise ultrasound guidance. This single injection integrates with the synovial tissue, providing cushioning and restores lost lubrication in the joint. By doing so, it helps to reduce knee pain and stiffness, while also improving mobility for patients with knee osteoarthritis.
The hydrogel is inert, non-biodegradable, and serves as a scaffold for synovial tissue ingrowth.
The treatment is ideal for those seeking an effective, long-term alternative to surgery or for those who are not yet candidates for a knee replacement.
What Arthrosamid Offers
Benefits of Arthrosamid® Injections
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Long-lasting pain relief Arthrosamid® provides sustained relief from joint pain, with studies reporting benefit lasting up to three years in many patients.
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Minimally invasive Performed as an outpatient procedure under local anaesthetic, Arthrosamid® does not require hospital admission or lengthy recovery times.
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Proven effectiveness Clinical trials have demonstrated a significant reduction in pain by Week 4, with relief lasting up to three years in many patients.
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Safety Arthrosamid® is a biocompatible injectable hydrogel; polyacrylamide gels have been used in medicine for many years.
A Tailored Treatment for Long-Term Relief
With its proven ability to reduce pain and stiffness while improving movement, Arthrosamid® offers patients lasting relief without surgery. Each treatment is delivered under the expert care of Consultant Orthopaedic Surgeon Dr Arj Imbuldeniya, using precise imaging to ensure safety and the best possible outcome. For many, it provides the missing link between short-term relief and more invasive options, helping restore comfort, confidence, and quality of life.
Arthrosamid® is designed for active adult patients suffering from moderate to severe knee osteoarthritis who are looking to delay or avoid knee replacement surgery. It is especially beneficial for those who have not responded to other injectable treatments, such as hyaluronic acid or PRP injections. Dr Imbuldeniya often recommends Arthrosamid® when other non-surgical treatments like physiotherapy and pain relief medication have not provided sufficient relief.
The procedure is quick and convenient. After the patient is given oral antibiotics and local anaesthetic to reduce infection risk, the injection site is located using ultrasound. The polyacrylamide hydrogel is then injected into the synovial capsule, where it integrates with the surrounding synovial tissue to provide cushioning and pain relief.
This entire process takes place in the clinic, allowing patients to return home the same day with minimal discomfort.
Most patients report significant pain relief within 4 weeks, and studies have reported sustained improvement for up to three years. While individual results may vary, the majority of patients find Arthrosamid® offers a much-needed alternative to surgery and allows them to maintain an active lifestyle.
Extensive clinical trials have shown that Arthrosamid® is effective in reducing pain and improving function in patients with knee osteoarthritis. Ongoing studies aim to confirm the long-term benefits, but many patients have already reported up to 156 weeks (3 years) of sustained pain relief from a single injection. While no treatment is 100% effective for everyone, Arthrosamid® has proven to be a valuable new treatment option for those with knee arthritis.
In a prospective study, Bliddal, H., et al. report that Arthrosamid® exceeded the MCID (minimal clinically important difference) of 9 points at six months, with improvement maintained in longer-term follow-up after a single injection.
Potential Side Effects
As with any medical procedure, there are potential side effects. These can include mild swelling, bruising, or pain at the injection site. In rare cases, infection or allergic reactions can occur. However, most patients tolerate the procedure well, with minimal adverse effects. We carefully monitor all patients after treatment to ensure their safety and comfort.
What to Expect from Your Arthrosamid® Treatment
From your first consultation through to the injection itself, every stage of the Arthrosamid® process is carefully designed to ensure safety, precision, and comfort.
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Initial Consultation Your journey begins with a detailed consultation with Dr Arj Imbuldeniya, Consultant Orthopaedic Surgeon and knee specialist. During this appointment, he will take time to understand your symptoms, review your medical history, and assess the severity of your knee osteoarthritis. You’ll have the opportunity to discuss previous treatments, your goals, and any concerns. Dr Imbuldeniya will then explain how Arthrosamid® works, what results to expect, and whether it’s the most appropriate option for your condition. -
Tests and Assessment If required, diagnostic imaging such as X-rays, MRI, or ultrasound will be arranged to provide a clear picture of your knee joint and confirm suitability for treatment. These tests help identify the extent of cartilage wear, joint inflammation, or other factors that could influence your outcome. The results allow Dr Imbuldeniya to tailor the treatment precisely to your needs and plan the injection using ultrasound guidance for maximum accuracy. -
The Injection Procedure The Arthrosamid® injection is a straightforward outpatient procedure that usually takes around 20 to 30 minutes. You’ll receive a local anaesthetic to minimise discomfort and oral antibiotics to reduce the risk of infection. Using real-time ultrasound, Dr Imbuldeniya accurately guides the injection into the synovial capsule of the knee joint, where the hydrogel integrates with the surrounding tissue to provide cushioning and long-term pain relief. Most patients can walk out of the clinic the same day and resume light activity the same day.
Arthrosamid Injection Cost in London
Our fees are published openly. An initial consultation is £350 and injectable treatments range from £500 to £3,500 depending on the treatment agreed. After your consultation you receive a fixed written quotation, so there are no surprises. Full details are on our fees page, and if you are weighing an injection against an operation, our guide to private knee replacement costs sets out the surgical side of the equation.
Arthrosamid®, PRP or Hyaluronic Acid: Which Injection Is Right for You?
The three injections do different jobs. Arthrosamid® is a non-biodegradable hydrogel that integrates with the lining of the joint to cushion the knee, a structural treatment for established osteoarthritis. High-dose PRP uses your own concentrated platelets to support the biology of the joint, and suits earlier disease and patients focused on keeping their knee active. Hyaluronic acid supplements the joint’s natural lubrication for shorter-term relief. We do the right things in the right order. Dr Arj offers all three under ultrasound guidance, so the recommendation you receive is based on what your knee needs, not on the only tool available.
Patient stories
Real feedback from our patients
Hear from patients about their experience of Arthrosamid® injections and consultant-led care at our clinic.
Calm care, treated in one visit
Dr Imbuldeniya has a very calm, reassuring bedside manner, which enabled him to to talk me through and carry out the injections to BOTH of my knees in one appointment.
Ceri
Needle phobia, positive experience
He has administered injections in BOTH of my knees on the same day! It was a great experience even though I am needle phobic and was a little nervous!
Ms Boulter
Book Your Consultation
If you're tired of living with knee pain and are interested in learning more about how Arthrosamid® could help, book a consultation today with Dr Imbuldeniya at OrthoLongevity in Mayfair. Our team of experts is here to guide you through your treatment options and provide you with a personalised plan to get you back on your feet.
Frequently Asked Questions
Many patients considering Arthrosamid® want to understand what to expect before treatment. Here are some of the most common questions we’re asked in clinic:
Clinical studies show that a single Arthrosamid® injection can provide pain relief and improved joint function for up to three years in many patients. Results vary depending on the severity of knee osteoarthritis, but most people notice improvement within four weeks of treatment.
The injection is performed under local anaesthetic to keep you comfortable throughout. You may feel mild pressure or brief discomfort during the procedure, but most patients describe it as well tolerated. Any tenderness at the injection site usually settles within a day or two.
Most patients are able to walk out of the clinic and resume light activity the same day. We generally recommend avoiding high-impact exercise for a few days to allow the joint to settle. Dr Imbuldeniya will provide specific guidance based on your activity level and recovery progress.
Yes. Arthrosamid® is often part of a wider treatment plan that may include physiotherapy, strength training, or lifestyle changes to support knee health. It can also be an option when other injections, such as hyaluronic acid or PRP, have not provided lasting relief.
With me, an Arthrosamid knee injection costs £3,500, given under ultrasound guidance. A first consultation is £350, and I only recommend Arthrosamid once we have agreed it is the right step for your knee.
Arthrosamid® is a permanent hydrogel that cushions the joint from within, designed for established knee osteoarthritis. PRP uses your own concentrated platelets to support the biology of the joint and suits earlier disease. Hyaluronic acid supplements the lubrication of the joint for shorter-term relief. They are different tools for different knees, and your consultation determines which, if any, is right for yours.
I give Arthrosamid injections at Lanserhof at The Arts Club in Mayfair, central London. Book a consultation on 0207 859 4016 or at admin@ortholongevity.co.uk.
Why Choose OrthoLongevity?
At OrthoLongevity, we pride ourselves on delivering Innovation, Compassion and Excellence. Led by Dr Arj Imbuldeniya, a highly experienced orthopaedic surgeon, our clinic has a proven track record of using advanced therapies such as Arthrosamid® to help patients regain mobility and improve their quality of life. With access to the latest technologies and a compassionate team dedicated to patient care, we are committed to finding the right treatment for everyone.
Patient Reviews
What Our Patients Say
Verified feedback from patients who have received care from Dr Arj Imbuldeniya and the team at OrthoLongevity.