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Other Knee Treatments
PRP Knee Injections in London
High-dose PRP knee injections in London with Dr Arj Imbuldeniya, a consultant knee surgeon. His protocol uses the Arthrex ACP Max system from a 60 to 90ml blood draw to deliver a far higher platelet dose than standard PRP, delivered under ultrasound guidance. Because he can offer injection, biological treatment or surgery, the advice is unbiased.
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If you’re living with knee pain caused by arthritis, tendon injury or overuse, Platelet-Rich Plasma (PRP) therapy offers a non-surgical option. This innovative treatment uses the healing properties of your own blood to reduce pain, improve mobility and support long-term joint health.
What Is PRP Therapy?
Platelet-Rich Plasma (PRP) injections, also known as Arthrex ACP Autologous Conditioned Plasma therapy, use a sample of your own blood to create a concentrated plasma rich in platelets and growth factors. These naturally occurring substances can settle inflammation in an arthritic knee and support the healing of tendons and muscle tissue, reducing pain. PRP does not regrow worn cartilage, but it can make the joint less painful and easier to strengthen.
PRP is used in the treatment of knee osteoarthritis, muscle tears, and tendon injuries around the patella area. By calming inflammation and supporting tissue healing, PRP can help patients delay or even avoid surgical intervention.
Does PRP Work for Knee Arthritis?
PRP can reduce pain and improve function in knee arthritis, but how well it works depends heavily on the dose, and that is the single most important thing to ask about before you pay for it. PRP is not one product. A small blood draw spun in a simple kit can deliver a fraction of the platelets of a large-volume, high-dose preparation, and the trials reflect that difference.
The clearest evidence on dose comes from a randomised trial of 150 patients with moderate knee arthritis published in Scientific Reports in 2021 (Bansal and colleagues). A single injection containing 10 billion platelets gave better pain, function and walking scores than hyaluronic acid, and the benefit was still there at one year. The researchers concluded that an absolute count of around 10 billion platelets is what makes the difference. A 2021 review of randomised trials in the American Journal of Sports Medicine (Belk and colleagues) also found PRP did better than hyaluronic acid overall. By contrast, the RESTORE trial in JAMA the same year (Bennell and colleagues) found that three injections of a standard, commercially prepared PRP were no better than saline at twelve months. That is not a contradiction. It is what you would expect if dose matters.
That is why, for arthritis, I always use a high-dose, leucocyte-poor preparation made from a 60 to 90ml blood draw, delivering around 10 billion platelets in a single ultrasound-guided injection. Leucocyte-poor matters in a joint, because the white cells in other preparations can add to inflammation. Tendon problems are different: there I usually use a course of three injections, often leucocyte-rich. PRP does not regrow cartilage and it is not a cure. Used at the right moment, alongside strength work and the foundations of joint health, it can buy real, useful time.
Bansal H et al. Sci Rep 2021;11:3971. Belk JW et al. Am J Sports Med 2021;49(1):249 to 260. Bennell KL et al. JAMA 2021;326(20):2021 to 2030.
Not all PRP is the same: why dose matters
Many standard PRP preparations are made from a small blood draw and delivers a modest platelet dose. My protocol is different. I use the Arthrex ACP Max system with a 60 to 90ml blood draw, producing a high-dose, leucocyte-poor preparation containing around 10 billion platelets at more than five times the concentration found in your bloodstream. The logic is simple: concentration times volume equals total dose, and total dose is what your knee actually receives.
There is a second difference. I am a consultant knee surgeon. That matters not because injections require an operating theatre, but because the decision to inject, to wait, or to operate should be made by someone who can offer all three and profits from none in particular. If PRP is not the right treatment for your knee, I will tell you.
How Does PRP Therapy Work?
Platelets are rich in bioactive proteins called growth factors, which play a central role in healing injured or inflamed tissue. When injected into the affected joint or tendon, PRP releases these growth factors to stimulate tissue repair, enhance collagen production and regulate inflammation.
This biological process can support healing in tendons, where blood supply is limited, and can calm the inflamed lining of an arthritic joint, which is why it can help patients with osteoarthritis or chronic tendon pain.
PRP therapy at OrthoLongevity is performed by Consultant Orthopaedic Surgeon Dr Arj Imbuldeniya at Lanserhof at The Arts Club in Mayfair, and in Chiswick and Brentford, using Arthrex ACP technology to ensure accuracy and consistency.
PRP Therapy at a Glance
Benefits of PRP Knee Injections
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Natural healing: Uses your own blood to support tissue repair, minimising the risk of allergic reaction or rejection.
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Minimally invasive: A straightforward outpatient procedure performed without the need for general anaesthetic or hospital admission.
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Fast recovery: Most patients can return to normal daily activities shortly after treatment, with individual guidance provided to support safe recovery.
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Versatile treatment: Used in the management of knee osteoarthritis, tendinopathy, and selected sports-related muscle and tendon injuries.
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Long-term benefit: May help reduce pain, improve joint function and support long-term joint health as part of a wider, personalised treatment plan.
A Personalised Approach to Joint Pain
PRP therapy bridges the gap between short-term pain relief and invasive surgery. Under the expert care of Dr Arj Imbuldeniya, each treatment plan is tailored to your condition, ensuring precision and optimal results. By supporting your body’s natural repair mechanisms, PRP helps restore comfort, confidence and mobility.
Every injection is delivered under real-time ultrasound guidance, so the preparation goes precisely where it is needed.
Key Information About Private PRP Knee Injections in London
PRP therapy bridges the gap between short-term pain relief and invasive surgery. Under the expert care of Dr Arj Imbuldeniya, each treatment plan is tailored to your condition, ensuring precision and optimal results. By supporting your body’s natural repair mechanisms, PRP helps restore comfort, confidence and mobility.
A blood sample is taken from your arm and processed in a centrifuge to separate the platelet-rich plasma. The concentrated plasma is then injected into the affected joint or tendon using a fine needle. Each session takes around 30 minutes and is performed in the clinic.
Stay hydrated for 24 hours before your appointment. If you take a blood thinner such as warfarin, rivaroxaban (Xarelto) or clopidogrel (Plavix), please tell us when you book. Never stop it on your own. We may ask you to pause it for 48 hours before the injection, but only if your prescribing doctor or GP agrees it is safe, because this lowers the risk of bleeding into the joint. Anti-inflammatory painkillers such as ibuprofen or naproxen can affect platelet function, so we may ask you to avoid them for two weeks beforehand. If you take aspirin or an anti-inflammatory on prescription, do not stop it without first checking with your prescribing doctor or GP. __DEL__ __DEL__
For knee osteoarthritis, a single high-dose PRP injection is usually given. Tendon problems are usually treated with a course of three injections of standard-dose PRP, each spaced two to three weeks apart.
You may experience mild soreness or swelling for up to 48 hours. This usually settles quickly. Avoid strenuous activity for a few days, then gradually return to normal exercise. Improvements are often noticed within a few weeks.
Potential Side Effects and Considerations
PRP therapy is considered very safe since it uses your own blood. Mild side effects such as temporary swelling, bruising or tenderness may occur but resolve quickly. Some patients may experience a short-term flare of pain after injection, which is part of the natural healing response.
Effectiveness can vary based on condition severity, overall health and adherence to post-treatment guidance. PRP can also complement other treatments such as hyaluronic acid injections, physiotherapy or arthroscopic surgery to enhance outcomes.
What to Expect from Your PRP Treatment
From your first consultation through to the injection itself, every stage of the PRP process is carefully designed to ensure safety, precision, and comfort.
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Initial Consultation Your journey begins with a detailed consultation with Dr Arj Imbuldeniya, Consultant Orthopaedic Surgeon and knee specialist. During this appointment, he will take time to understand your symptoms, review your medical history, and assess the severity of your knee osteoarthritis. You’ll have the opportunity to discuss previous treatments, your goals, and any concerns. Dr Imbuldeniya will then explain how PRP works, what results to expect, and whether it’s the most appropriate option for your condition. -
Tests and Assessment If required, diagnostic imaging such as X-rays, MRI, or ultrasound will be arranged to provide a clear picture of your knee joint and confirm suitability for treatment. These tests help identify the extent of cartilage wear, joint inflammation, or other factors that could influence your outcome. The results allow Dr Imbuldeniya to tailor the treatment precisely to your needs and plan the injection using ultrasound guidance for maximum accuracy. -
The Injection ProcedureYour PRP injection is a straightforward outpatient procedure that usually takes around 30 to 40 minutes. A sample of your blood is taken, prepared in a centrifuge to concentrate the platelets, and injected into the knee under ultrasound guidance for precision, with a local anaesthetic to keep you comfortable throughout.
Patient stories
Real feedback from our patients
Verified reviews from patients treated for knee pain using PRP therapy.
Clear explanations
Doctor is brilliant. He spends time to understand and explains very well. Very empathetic. Great experience. The staff are also brilliant.
Vidya Laxman
Needle phobia, positive experience
He has administered injections in BOTH of my knees on the same day! It was a great experience even though I am needle phobic and was a little nervous!
Ceri Boulter
Book Your Consultation
If you’re struggling with knee pain and want to explore the benefits of PRP knee injections, book a consultation with Dr Arj Imbuldeniya at OrthoLongevity in Mayfair. We’ll review your symptoms, explain your options and create a treatment plan designed to help you move more freely with less pain.
PRP Knee Injection Cost in London
High-dose PRP for knee arthritis is a single injection of Arthrex ACP Max, made from a 60 to 90ml blood draw, and costs £2,050. Standard PRP (Arthrex ACP), which I use mainly for tendon problems as a course of three, costs £950 per injection. Both are given under ultrasound guidance. A first consultation is £350. Whether PRP is right for you depends on your knee, your goals and what we have already tried, and I will tell you plainly if I do not think it is the right step. Every fee I charge is on my pricing page.
Frequently Asked Questions
Many patients considering PRP injections want to understand what to expect before treatment. Here are some of the most common questions we’re asked in clinic:
The benefit varies from patient to patient. Many people notice improvement within a few weeks, and the effect commonly lasts many months to a year or more, depending on the state of the joint and the biology being treated. At your consultation Dr Arj will give you an honest view of what PRP can realistically achieve for your knee.
The injection is performed under local anaesthetic to keep you comfortable throughout. You may feel mild pressure or brief discomfort during the procedure, but most patients describe it as well tolerated. Any tenderness at the injection site usually settles within a day or two.
Most patients are able to walk out of the clinic and resume light activity the same day. We generally recommend avoiding high-impact exercise for a few days to allow the joint to settle. Dr Imbuldeniya will provide specific guidance based on your activity level and recovery progress.
Yes. PRP is often part of a wider treatment plan that may include physiotherapy, strength training, or lifestyle changes to support knee health. It can also be an option when other injections, such as steroid or hyaluronic acid, have not provided lasting relief.
With me, high-dose PRP for knee arthritis is a single ultrasound-guided injection costing £2,050. Standard PRP, used mainly for tendons as a course of three, is £950 per injection. A first consultation is £350.
Randomised trials suggest PRP gives better pain and function scores than hyaluronic acid, and a trial using around 10 billion platelets found the benefit lasted a year. Dose matters, and the right choice depends on your knee and what has already been tried.
High-dose PRP is a preparation that delivers a large absolute number of platelets, around 10 billion in my case, made from a 60 to 90ml blood draw rather than the small draw used in many standard kits.
Why Choose OrthoLongevity?
At OrthoLongevity, we deliver care built on innovation, compassion and clinical excellence. Led by Dr Arj Imbuldeniya, our clinic uses advanced therapies within our holistic Ortholongevity™ approach to help patients regain mobility and improve their quality of life. With access to the latest technologies and a dedicated, compassionate team, we focus on finding the right treatment for every individual.
Patient Experience
Real Feedback from Our Patients
Verified Doctify reviews from patients who have received PRP knee treatment at OrthoLongevity.